FORMULATION AND IN VITRO EVALUATION OF EPROSARTAN CONTROLLED RELEASE TABLETS

Abstract

Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablets/capsules. The present research work is to develop oral thin films of Clobazam by using solvent casting method. Oral thin films were developed by using various super disintegrants like Lycoat and crospovidone in different concentrations with Gelatin, Xanthan Gum as a film forming agents. The prepared formulations of films were evaluated for film thickness measurement, folding endurance study, in-vitro disintegration time, in-vitro drug release pattern (in pH 6.8 phosphate buffer). Drug content, and drug-polymers interaction study (IR spectroscopy). Among all formulations, the formulation (F12) prepared by 135 mg of Crospovidone show good drug release (99.25±1.45%). The Optimized formulation F12 follows first order.