FORMULATION AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLETS OF NIZATIDINE

Abstract

Objectives: The purpose of present investigation was to develop and evaluate floating drug delivery system of an Anti-Hyperlipidemic Agent.
Methods: The floating tablets of Nizatidine were prepared by using PEO (Polyethylene oxide), Guar Gum, Xanthan gum, Sodium alginate polymers. The pre-compression and post-compression evaluation were performed as per pharmacopoeial standards. The tablets were prepared by direct compression method. Dissolution measurements were carried out in a (USP) dissolution testing apparatus II.
Results: Compatibility study was performed by FTIR. The compatibility study of the prepared Nizatidine floating tablets confirms that there is no interaction between the drug and polymers used. The release data were subjected to different models in order to evaluate their release kinetics and mechanisms. The drug release kinetics was observed by super case II transport mechanism. The floating lag time were found to be significantly increased with the increasing concentration of the polymers.
Interpretation & Conclusion: After the dissolution study of prepared Nizatidine floating tablet it was concluded that the formulation F12 with Sodium alginate 100mg shows better sustained release effect i.e the drug release was 99.24±1.45% at the end of 12th hour. The release kinetic data implies that the release mechanism of all the formulations was super case II transport mechanism. The developed floating tablets of Nizatidine may be used to prolong drug release for at least 12h, thereby improving the bioavailability and patient compliance.