World Journal of Pharmaceutical Sciences
https://www.wjpsonline.com/index.php/wjps
<p><strong>The World Journal of Pharmaceutical Sciences (WJPS; Print ISSN: 2321-3310; Online </strong><strong>ISSN: 2321-3086)</strong> is an international, peer-reviewed monthly open-access journal published by Atom and Cell Publishers. The journal welcomes original research articles, review articles, short communications, mini-reviews, case reports, letter to the editor, guest editorial or commentaries and editorials of all aspects of pharmacy and pharmaceutical sciences.</p> <p><strong>Why publish with WJPS</strong></p> <p><strong>Impact Factor: 1.318</strong></p> <p><strong>Crossref DOI Assigned: 10.54037/WJPS</strong></p> <p><strong>Quick Quality Review: </strong>The journal has strong international team of editors and reviewers. Constructive reviews from renowned scientist and researcher at all editorial levels.</p> <p><strong>Rapid Decision and Publication:</strong> We guarantee a review of your manuscript by a panel of qualified experts within 15 days of submission. Authors that need a faster decision can request Fast Track review and get a response in 3-5 business days.</p> <p><strong>Indexing</strong>: Google Scholars; Advanced Science Index; Chemical Abstracts Service; Cosmos Impact Factor; CiteFactor; Directory of Research Journals Indexing; Eurasian Scientific Journal Index; Geneva Foundation for Medical Education and Research; Global Impact Factor; Index Copernicus; InfoBase Index; International Impact Factor Services; International Scientific Indexing; Open Academic Journals Index; Polish Scholarly Bibliography; Scholarsteer</p> <p><strong>Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. WJPS only charges the fees necessary to recoup costs associated with running the journal.</p> <p>You may submit manuscripts online through following link <a href="https://wjpsonline.com/index.php/wjps/about/submissions" target="_blank" rel="noopener">https://wjpsonline.com/index.php/wjps/about/submissions</a> or as an email attachment to the following mail: editor.wjps@gmail.com</p>Atom & Cell Publishersen-USWorld Journal of Pharmaceutical Sciences2321-3310Stability Indicating RP-HPLC Method for Simultaneous Estimation Of Remogliflozin And Teneligliptin
https://www.wjpsonline.com/index.php/wjps/article/view/1487
<p>A straightforward, accurate, and exact technique for estimating Remogliflozin and Teneligliptin in pharmaceutical dose form was devised. The chromatogram was done via an Ascentis 150 x 4.6 mm, 5m column. 0.01N Kh2:30 is present in the mobile phase. Acetonitrile in the 70:30 ratio was pushed through the column at a flow rate of 1.0ml/min. The retention time of Remogliflozin and Teneligliptin was determined to be 2.271 minutes and 2.706 percent RSD of Remogliflozin and Teneligliptin were found to be 0.6 and 0.5, respectively. %Remogliflozin and Teneligliptin recovered at 99.73% and 99.63%, respectively. The LOD and LOQ values derived from Remogliflozin and Teneligliptin regression models were 0.01, 0.04 and 0.48, 1.47, respectively. Teneligliptin's regression equation is y 40715x + 60.86, whereas Remogliflozin's is y = 16468x + 2301. Retention periods</p>L.Swathi
Copyright (c) 2024 L.Swathi
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2024-01-032024-01-03ESTIMATION OF VILOXAZINE BY USING RP- HPLC METHOD
https://www.wjpsonline.com/index.php/wjps/article/view/1485
<p>The RP-HPLC technology was used to produce a straightforward, precise, and easy-to-understand approach for the quantification of Viloxazine. The conditions used in chromatography are the stationary phase The Azilent measuring 150 mm x 4.6 mm x 5 meters The following parameters were maintained: mobile phase diluent: 0.01N KH2po4: acetonitrile in a 70:30 ratio; flow rate: 1.0 ml/min; detection wavelength: 222 nm; column temperature: 30oC; and so on. Conditions were fine-tuned to provide the best possible outcome. The findings of studying the system suitability characteristics by injecting the standard six times were much lower than the acceptability criterion. After conducting a linearity analysis from 25% to 150%, the R2 value was determined to be 0.999. The results showed that the repeatability was 0.6 and the intermediate precision was 0.4.2. The limits of detection (LOD) are 0.07μg/ml and the limits of quantification (LOQ) are 0.20μg/ml. With the aforementioned procedure, 99.86% of the advertised formulation was detected. In all cases, the purity threshold was more than the purity angle and within the permissible range, according to the Viloxazine degradation experiments. We did not conduct a full-length technique analysis; nonetheless, this approach has the potential to be used for regular Viloxazine analysis</p>Dr. K. Swathi Priya
Copyright (c) 2024 Dr. K. Swathi Priya
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2024-01-032024-01-03SIMULTANEOUS ESTIMATION OF THE PREGABALIN AND ETORICOXIB IN TABLET DOSAGE FORM BY USING RP-HPLC METHOD
https://www.wjpsonline.com/index.php/wjps/article/view/1483
<p>A simple, Accurate, precise method was developed for the simultaneous estimation of the Pregabalin and Etoricoxib in Tablet dosage form. Chromatogram was run through Agilent C18 150 x 4.6 mm, 5m. Mobile phase containing Buffer 0.01N KH2PO4: Acetonitrile taken in the ratio 50:50 was pumped through column at a flow rate of 0.8 ml/min. Buffer used in this method was 0.01N KH2PO4 buffer. PH adjusted to 5.4 with dil. Orthophosphoric acid solution. Temperature was maintained at 30°C. Optimized wavelength selected was 240.0 nm. A simple, Accurate, precise method was developed for the simultaneous estimation of the Pregabalin and Etoricoxib in Tablet dosage form. Retention time of Pregabalin and Etoricoxib were found to be at 2.302 min and 3.219 min %RSD of the Pregabalin and Etoricoxib were and found to be 0.5 and 0.6 respectively. %Recovery was obtained as 100.27% and 100.22% for Pregabalin and Etoricoxib respectively. LOD, LOQ values obtained from regression equations of Pregabalin and Etoricoxib were 0.27, 0.83 and 0.24, 0.72 respectively. Regression equation of Pregabalin is y = 23826x + 8530.6 y = 27243x + 3474.3 of Etoricoxib. Retention times were decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.</p>L.Swathi
Copyright (c) 2024 L.Swathi
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2024-01-032024-01-03Method Development and Validation of Simultaneous Estimation of Cabotegravir and Rilpivirine Using RP-HPLC Method
https://www.wjpsonline.com/index.php/wjps/article/view/1488
<p>For the simultaneous estimate of Cabotegravir and Rilpivirine in pharmaceutical dose form, a simple, accurate, and exact approach was established. BDS C8 150 x 4.6 mm, 5m chromatogram was done. A mobile phase containing 0.1% orthophosphoric acid:acetonitrile in a 50:50 ratio was pushed down the column at a flow rate of 1.0 ml/min. 0.1% Ortho phosphoric acid buffer was utilized in this procedure. The temperature was kept at 30°C. The optimal wavelength chosen was 257 nm. Cabotegravir and Rilpivirine retention times were determined to be 2.950 min and 3.518.%RSD of Cabotegravir and Rilpivirine were found to be 0.8 and 0.5, respectively. %Cabotegravir and Rilpivirine recovery rates were 99.19% and 98.90%, respectively. LOD and LOQ values derived from regression</p>L.Swathi
Copyright (c) 2024 L.Swathi
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2024-01-032024-01-03METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION OF OLANZAPINE AND SAMIDORPHAN BY USING RP –HPLC METHOD
https://www.wjpsonline.com/index.php/wjps/article/view/1486
<p>The estimate of Samidorphan and Olanzapine in tablet form is simple, accurate, and precise. Chromatograms were examined using ZORBAX Eclipse Plus C18, 4.6mm x 100mm, 5 μm. A 0.01N Ammonium Formate: Acetonitrile 80:20 mobile phase was pumped through the column at 1 ml/min. Temperature was 30°C. The optimal wavelength was 268 nm. Retention time of Samidorphan and Olanzapine was 2.232min and 2.706, respectively. %RSD was 0.4 and 0.2. Samidorphan recovered 99.80% and Olanzapine 99.77%. LOD, LOQ values from regression equations of Samidorphan and Olanzapine were 0.06, 0.17, 0.09, 0.28. Samidorphan and Olanzapine regression equations are y = 31939x + 4951.1. The method was simple and economical, reducing retention and run times for regular quality control tests in industries. Regression equations for Samidorphan and Olanzapine are 31939x + 4951.1 and 37650x + 4959.1, respectively. Retention times and run time were reduced, making the method simple and cost-effective for industrial quality control tests.</p>L. Swathi
Copyright (c) 2024 L. Swathi
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2024-01-032024-01-03ESTIMATION OF TRILACICLIB BY USING RP-HPLC METHOD
https://www.wjpsonline.com/index.php/wjps/article/view/1484
<p>A simple, precise, and accurate RP-HPLC method was devised to estimate Trilaciclib. Stationary phase Agilent C18 (150mm*4.6mm3.6m), mobile phase 0.01N KH2PO4: Methanol in the ratio 55:45, flow rate 0.9ml/min, detection wave length 253nm, column temperature 30oC, and diluent mobile phase. Optimized conditions were set. System appropriateness characteristics were examined by injecting the standard six times and scoring considerably below acceptability. R2 was 0.999 for linearity study between 25% and 150%. Precision was 0.9 for repeatability and 0.7 for intermediate. The LOD and LOQ are 0.14μg/ml and 0.41μg/ml, respectively. The aforesaid approach assayed commercial formulation and found 100.31%. All Trilaciclib degradation investigations showed purity thresholds greater than purity angle and within acceptable limits. Full length approach was not conducted; if done, it may be utilized for ordinary Trilaciclib analysis.</p>A. Kanaka Durga Valli
Copyright (c) 2024 A. Kanaka Durga Valli
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2024-01-032024-01-03