FORMULATION AND EVALUATION OF IBUPROFEN TRANSDERMAL PATCHES

Abstract

The purpose of this research was to develop a transdermal patches containing drug Ibuprofen with different ratios of Eudragit L 100, Sodium Alginate, Chitosan polymeric systems by the solvent casting method by using to Propylene Glycol as plasticizer. Different concentrations of Dichloromethane and Tween80 were used to enhance the transdermal permeation of Ibuprofen. The physicochemical compatibility of the drug and the polymers studied by differential scanning calorimetry and infrared spectroscopy suggested absence of any incompatibility. Formulated transdermal films were physically evaluated with regard to thickness, weight variation, drug content, folding endurance, percentage of moisture content. All prepared formulations indicated good physical stability. In-vitro permeation studies of formulations were performed by using Franz diffusion cells. Formulation F12 containing 200mg of Chitosan shows maximum drug permeation rate within 12hrs. Kinetic models were used to confirm release mechanism of the formulations. Ibuprofen release from the patch F12 followed Zero order kinetics and shows super case II transport mechanism.