FORMULATION AND IN VITRO EVALUATION OF DASATINIB FLOATING MICROSPHERES

Abstract

Dasatinib is a tyrosine kinase inhibitor used for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia or chronic myeloid leukemia. The present work is formulation of Dasatinib floating microspheres by using xanthan gum, Eudragit S100 and Ethyl Cellulose. All the formulations were subjected for preformulation evaluation. Results of preformulation studies, FTIR, SEM, particle size and size distribution, % yield, drug content, buoyancy time, entrapment efficiency, in vitro dissolution and release kinetics. The FTIR Spectra revealed that, there was no interaction between polymers and Dasatinib. On the basis of release data of Dasatinib formulation F12 showed a good controlled release profile with maximum entrapment efficiency because of optimum polymer concentration i.e., 1:4 ratio (Eudragit S100) with sodium alginate than other drug: polymer ratios. The invitro dissolution data for best formulation F12 were fitted in different kinetic models i.e, zero order, first order, Higuchi and korsemeyer-peppas equation. Optimized formulation F12 shows zero order drug release with Super case II transport mechanism.