FORMULATION AND EVALUATION OF NANOSUSPENSION OF MACITENTAN BY EMULSIFICATION SOLVENT EVAPORATION METHOD

Abstract

The aim of the present work is to develop oral Nanosuspension of Macitentan by Emulsification solvent evaporation method using various Stabilizers & Surfactants such as Poloxamer-188, PVP K30, Pluronic® F-127, and SLS. Various formulation as well as process parameters were optimized in order to achieve desirable size and saturation solubility. Characterization of the prepared Nanosuspension was done with respect to particle size, zeta potential, saturation solubility, dissolution rate, morphology study (SEM), in-vitro dissolution study. Average particle size of Nano suspension of optimized formulations (NS12) was found to be 261.5 nm. From the in-vitro Diffusion studies we can say that formulation NS12 shows best drug release of 99.12±1.30%, within 30 minutes whereas all the other formulations didn’t release the drug. The drug release from the Nanosuspension was explained by the using mathematical model equations such as zero order, first order, and equation methods. Based on the regression values it was concluded that the optimized formulation NS12 follows First order kinetics.