Solid dispersion and air suspension techniques for obtaining controlled drug delivery system containing ketorolac and paracetamol

Authors

  • El-Gizawy S. A Pharm. Technology and Analytical chemistry Dept•, Faculty of Pharmacy, Tanta University, Tanta, Egypt
  • Zein El Din E. E Pharm. Technology and Analytical chemistry Dept•, Faculty of Pharmacy, Tanta University, Tanta, Egypt
  • Sherin Hammad Pharm. Technology and Analytical chemistry Dept•, Faculty of Pharmacy, Tanta University, Tanta, Egypt
  • Yassin H. A Pharm. Technology and Analytical chemistry Dept•, Faculty of Pharmacy, Tanta University, Tanta, Egypt

Keywords:

Ketorolac and paracetamol synergistic effect, First derivative spectrophotometric assay, of ketorolac and paracetamed, ketorolac delivery system, ketorolac solid dispersion technique

Abstract

The present study reports on the formulation of ketorolac tromethamine loaded Eudragit RS100, Eudragit RL100 as well as Ethyl cellulose as a controlled release drug delivery system. Solid dispersion and microencapsulation by air suspension method were the techniques for choice. Paracetamol was added to the prepared formulations in the form of physical mixture in order to make use of the synergistic effect of the drug with different non-steroidal anti-inflammatory drugs (NSAIDs).  

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Published

2014-08-01

How to Cite

El-Gizawy S. A, Zein El Din E. E, Sherin Hammad, & Yassin H. A. (2014). Solid dispersion and air suspension techniques for obtaining controlled drug delivery system containing ketorolac and paracetamol. World Journal of Pharmaceutical Sciences, 2(8), 765–774. Retrieved from https://www.wjpsonline.com/index.php/wjps/article/view/solid-dispersion-air-suspension-techniques-ketorolac-paracetamol

Issue

World J Pharm Sci 2014; 2(8): 693-889

Section

Research Article

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