FORMULATION AND EVALUATION OF ISOSORBIDE DINITRATE BUCCAL TABLETS

Abstract

In the present study, an attempt was made to prepare Buccal tablets of Isosorbide dinitrate, in order to overcome bioavailability problems, to reduce dose dependent side effects. Buccal tablets containing the drug were prepared by direct compression method using combinations of polymers (such as Guar gum, Carbopol 940, Xanthan Gum and Pectin). Estimation of Isosorbide dinitrate was carried out spectrophotometrically at 405 nm. The Buccal tablets were evaluated for various physical and biological parameters, drug content uniformity, in-vitro drug release, drug-excipient interactions (Infrared Red). FTIR spectroscopic studies indicated that there are no drug-excipient interactions. The formulations F12 (containing 45mg of Pectin) were found to be promising, which showed maximum drug release within 8hrs. These formulations have displayed good bioadhesion strength (29.12±1.18 gm respectively).