REVIEW ON FORMULATION AND INVITRO EVALUATION OF BILAYER TABLETS

Abstract

Bilayer tablets have emerged as a viable strategy in drug delivery systems, with the ability to combine two unique layers with varied release patterns or drug combinations in a single dosage form. This method is particularly useful for administering incompatible medications, sequential drug release, and controlled distribution of a single active medicinal component. This paper includes a thorough discussion of formulation methodologies, bilayer tablet designs, and the issues encountered during development, such as layer separation, inadequate hardness, and cross contamination. Various approaches to addressing these issues are described, including the use of modified granulation methods and improved compression equipment. The study also emphasizes essential assessment factors including as hardness, friability, weight fluctuation, drug content homogeneity, and in vitro dissolving investigations, which are critical for ensuring the quality and efficacy of bilayer tablets. Advances in bilayer tablet technology, regulatory issues, and future prospects for pharmaceutical development are all discussed. This study intends to be a beneficial resource for academics and formulators working on bilayer tablets to improve therapeutic results.